Introduction:This study was aimed to investigate significant contribution of coping strategies by mediated emotion regulation cognitive styles in college students' quality of life.

Method:The present research method was correlational .Statistical population was included all undergraduate and graduate students of Isfahan University in second semester of 2013-2014 academic years. Participants also were 340 male and female students that were selected by multistage cluster sampling method among 13 Faculties. Tools were Cognitive Emotion Regulation Questionnaire (CERQ), Way of Coping Questionnaire (WOCQ) and World health organization Quality of Life brief scale (WHO-QOL-BREF1). The data were analyzed by path analysis and structural equation modeling.

Results:The findings showed that: a)Problem-focused and emotion-focused coping strategies mediated by cognitive emotion regulation styles were considered powerful predictor and meaningful of quality of life for students. Standardized effects of positive and negative cognitive emotion regulation styles on students' quality of life were significant. B) There was no significant relationshipbetween emotion based coping strategies and quality of lifeand problem-focusedcoping strategiesand quality of lifehavestatisticallysignificant relationship. C)Positive and negative style of cognitive emotion regulation showed significant relationshipwith quality of life.

Conclusion: Despite all the limitations which individuals were experienced in college, enhancement of emotional competence and skills could be possible through training in proper emotion regulation in form of authentic training packages of cognitive - behavioral style and styles of problem-focused coping with demands and constraints of environmental stresses to enrich quality of life of this influential segment of society.